1. Remontet L, Esteve J, Bouvier AM, Grosclaude P, Launoy G, Menegoz F. et al. Incidence et mortalité des cancers en France sur la période 1978-200. Rev Epidemiol Santé Publique 2003 ; 51 :3-30 2. Fayçal J, Bessaguet C, Nousbaum JB, Cauvin JM, Cholet F, Bideau K et al. Epidémiologie et survie à long terme des adénocarcinomes gastriques dans le Finistère entre 1984 et 1995. Gastroenterol Clin Biol 2005;29:23-32. 3. Andriulli A, Recchia S, De Angelis C, Mazzucco D, Berti E, Arrigoni A et al. Endoscopic evaluation of patients with biopsy negative gastric linitis plastica. Gastrointest Endosc 1990; 36: 611-4 4. Caldas C, Carneiro F, Lynch HT, Yokota J, Wiesner GL, Powell SM et al. Familial gastric cancer overview and guidelines for management. J Med Genet 1999;36:873-80. 5. Lewis FR, Mellinger JD, Hayashi A, Lorelli D, Monaghan KG, Carneiro F et al. Prophylactic total gastrectomy for familial gastric cancer. Surgery 2001;130:612-7 6. Gouzi JL, Huguier M, Fagniez PL, Launois B, Flamant Y, Lacaine F et al. Total versus subtotal gastrectomy for adenocarcinoma of the gastric antrum. Ann Surg 1989; 209:162-8 7. Bozzetti F, Marubini E, Bonfanti G, Miceli R, Piano C, Gennari L. Subtotal versus total gastrectomy for gastric cancer : five year survival rates in a multicenter randomized Italian trial. Italian Gastrointestinal Tumor Study Group. Ann Surg 1999; 230: 170-8. 8. Bonenkamp JJ, Hermans J, Sasako M, van de Velde CJ and the Dutch Gastric cancer group. Extended lymph node dissection for gastric cancer. N Engl J Med 1999; 340: 908-14 9. Siewert JR, Kestlmeier R, Busch R, Bottcher K, Roder JD, Muller J et al. Benefits of D2 lymph node dissection for patients with gastroc cancer and pN0 and pN1 lymph node metastases. Br J Surg 1996; 83: 1144-7 10. Cuschieri A, Fayers P, Fielding J, Craven J, Bancewicz J, Joypaul V et al. Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial. The Surgical Cooperative Group. Lancet 1996; 347: 995-9. 11. Cuschieri A, Weeden S, Fielding J, Bancewicz J, Craven J, Joypaul V et al. Patient survival after D1 and D2 resection for gastric cancer: long term results of the Medical Research Council (MRC) randomized surgical trial. Br J Cancer 1999; 79: 1522-30 12. Hartgrink HH, Van de Velde CJH, Putter H, Bonenkamp JJ, Klein Kranenbarg E, Songun I et al. Extended lymph node dissection for gastric cancer: who may benefit ? Final results of the randomized Dutch Gastric Cancer Group Trial. J Clin Oncol 2004; 22: (11): 2069-77. 13. McCulloch P, Eidi Niita M, Kazi H, Gama-Rodrigues JJ et al. Gastrectomy with extended lymphadenectomy for primary treatment of gastric cancer. Br J Surg 2005; 92: 5-13. 14. Bunt AM, Hermans J, Boon MC et al. Evaluation of the extent of lymphadenectomy in a randomized trial of western-versus Japanese surgery in gastric cancer. J Clin Oncol 1994; 12: 417-22. 15. Degiuli M, Sasako M, Calgaro M, Garino M, Rebecchi F, Mineccia M et al. Morbidity and mortality after D1 and D2 gastrectomy for cancer: interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial. Eur J Surg Oncol 2004;30:303-8 16. Cunningham D, Allum W, Stenning S, Thompson J, Van de Velde C, Nicholson M et al. Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer N Engl J Med 2006; 355:11-20 17. Hermans J, Bonenkamp JJ, Boon MC, Bunt AM, Ohyama S, Sasako M et al. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trial. J Clin Oncol 1993; 11: 1441-7 18. Pignon JP, Ducreux M, Rougier P. Meta-analysis of adjuvant chemotherapy in gastric cancer: a critical reappraisal. J Clin Oncol 1994; 12: 877-8 19. Earle CC, Maroun JA. Adjuvant chemotherapy after curative resection for gastric cancer in non-asian patients: revisiting a meta-analysis of randomized trials. Eur J Cancer 1999; 35: 1059-64 20. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345: 725-33 21. Hundahl SA, Macdonald JS, Benedetti J, Fitzsimmons T; Southwest Oncology Group and the Gastric Intergroup. Surgical treatment variation in prospective, randomized trial of chemoradiotherapy in gastric cancer: the effect of under treatment. Ann Surg Oncol 2002;9: 278-86. 22. Dahan L, Atlan D, Bouche O, Mitry E, Ries P, Artru P et al. Postoperative radiochemotherapy after surgical resection of adenocarcinoma of the stomach : can we reduce the toxic effects of Mac Donald regimen by using LV5FU2 ? Gastroenterol Clin Biol 2005; 29:11-5 23. Smalley SR, Gunderson L, Tepper J, Martenson JA, Minsky B, Willet C et al. Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implantation. Int J Radiation Oncology Biol Phys 2002; 52:283-93. 24. Caudry M, Ratoanina JL, Escarmant P, Maire JP. Les volumes cibles de la radiothérapie des adénocarcinomes gastriques. Cancer/radiother 2001 ; 5 : 523-33. 25. Webb A, Cunningham D, Scarffe JH, Harper P, Norman A, Joffe JK et al. Randomized trial comparing epirubicin, cisplatin an fluorouracil versus fluouracil, doxorubicin and methothrexate in advanced esophagogastric cancer. J Clin Oncol 1997;15:261-7 26. Waters JS, Norman A, Cunningham D, Scarffe JH, Webb A, Harper P et al. Long-term survival after Epitubicin, Cisplatin and Fluorouracil for gastric cancer: results of a randomized trial. Br J Cancer 1999; 80: 269-72. 27. Ross P, Nicholson M, Cunningham D, Valle J, Seymour M, Harper P et al. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol 2002; 20:1996-2004 28. Rougier Ph, Ducreux M, Majhoubi M, Pignon JP, Belleqih S, Oliviera J et al. Efficacy of combined 5-fluorouracil and cisplatinum in advanced gastric carcinomas. A phase II trial with prognostic factor analysis. Eur J Cancer 1994; 30: 1263-9 29. Mitry E, Taieb J, Artru P, Boige V, Vaillant JN, Clavero-Fabri MC et al. Combination of folinic acid, 5-fluorouracil bolus and infusion, and Cisplatin (LV5FU2-P regimen) in patients with advanced gastric or gastroesophageal junction carcinoma. Ann Oncol 2004 ; 15 (5) : 765-9. 30. Ychou M. , Pignon P., Lasser P., Conroy T., Bouché O., Boige V., Segol P., Bedenne L., Saint-Aubert B., Rougier P. Phase III preliminary results of preoperative fluorouracil and cisplatin versus surgery alone in adenocarcinoma of stomach and lower esophagus: FNLCC 94012-FFCD9703 trial. J Clin Oncol 2006 ASCO Annual Meeting Proceedings; 24:4026 31. Cunningham D, Rao S., Starling N., Iveson T., Nicolson M., Coxon F., Middleton G., Daniel F., Oates J., Norman AR. Randomised multicentre phase III study comparing Capecitabine with Fluorouracil and Oxaliplatin with Cisplatin in patients with advanced oesophagogastric cancer: the REAL 2 trial. J Clin Oncol 2006 ASCO Annual Meeting Proceedings; 24: 4017 32. Bouché O, Raoul JF, Bonnetain F, Giovannini M, Etienne PL, Lledo G et al. Randomized multicenter phase II trial of a biweekly regimen of fluorouracil and leucovorin (LV5FU2), LV5FU2 plus cisplatin, or LV5FU2 plus irinotecan in patients with previously untreated metastatic gastric cancer: a Federation Francophone de Cancerologie Digestive Group Study--FFCD 9803. J Clin Oncol. 2004;22:4319-28. 33. Moiseyenko V, Ajani JA, Tjulandin S, Majlis A, Constenla M, Boni M et al. Final results of a randomized controlled phase III trial (TAX 325) comparing docetaxel (T) combined with cisplatin (C) and 5-fluorouracil (F) to CF in patients (pts) with metastatic gastric adenocarcinoma (MGC) . Proc Am Soc Clin Oncol 2005;24:4002a 34. Thuss-Patience PC, Kretzschmar A, Repp M, Kingreen D, Hennesser D, Micheel S et al. Docetaxel and Continuous -Infusion Fluorouracil Versus Epirubicin, Cisplatin, and Fluorouracil for Advanced Gastric Adenocarcinoma: A Randomized Phase II Study. J Clin Oncol. 2005;23:494-501. 35. Shin D, Cho E, Lee WK et al. A phase II trial of Epirubicin, Cisplatin and Capecitabine combinaison chemotherapy for previously untreated advanced gastric cancer. Proc Am Soc Clin Oncol 2003; 22: 1318a. 36. Cho EK, Lee WK, Im SA, Lee SN, Park SH, Bang SM, Shin DB, Lee JH. Epirubicin, Cisplatin and Capecitabine in first-line chemotherapy for patients with advanced gastric cancer. Proc Am Soc Clin Oncol 2004; 23: 4074 a. 37. Wöhrer SS, Raderer M, Hejna M. Palliative chemotherapy for advanced gastric cancer. Ann Oncol 2004; 15: 1585-1595. 38. Shah MA, Scwartz GK. Treatment of metastatic oesophagus and gastric cancer. Semin Oncol 2004; 31:574-587. 39. De Vita F, Orditura M, Matano E, Bianco R, Carlomagno C, Infusino S et al A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. Br J Cancer 2005; 92: 1644-9 40) Glehen O, Schreiber V, Cotte E, Sayag-Beaujard AC, Osinsky D, Freyer G, et al. Cytoreductive surgery and intraperitoneal chemohyperthermia for peritoneal carcinomatosis arising from gastric cancer. Arch Surg 2004;139:20-6. 40. Gilly FN, Carry PY, Sayag AC, Brachet A, Panteix G, Salle B et al. Regional chemotherapy (with mitomycin C) and intra-operative hyperthermia for digestive cancers with peritoneal carcinomatosis. Hepatogastroenterology 1994;41 124-9 41. Yoo CH, Noh SH, Shin DW, Choi SH, Min JS. Recurrence following curative resection for gastric carcinoma. Br J Surg 2000 ;87 :236-42 42. Maehara Y, Hasuda S, Koga T, Tokunaga E, Kakeji Y, Sugimachi K. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer. Br J Surg 2000 ;87 :353-7 43. Nguyen, C Rebischung, J Van Ongeval, M Flesch, M Bennamoun, T André, M Ychou, E Gamelin, E Carola, C Louvet. Epirubicin-docetaxel in advanced gastric cancer : two phases II studies as first line treatment. Bull Cancer 2006, 93(1); E1-6. 44. Al-Batran S., Hartmann J., Probst S., Hofheinz R., Stoehlmacher J., Schmalenberg H., Hollerbach S., Schuch G., Homann N., Jäger E. A randomized phase III trial in patients with advanced adenocarcinoma of the stomach receiving first-line chemotherapy with fluorouracil, leucovorin and oxaliplatin (FLO) versus fluorouracil, leucovorin and cisplatin (FLP) Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings 24 : 4016 45. Glehen O, Schreiber V, Cotte E, Sayag-Beaujard AC, Osinsky D, Freyer G, et al. Cytoreductive surgery and intraperitoneal chemohyperthermia for peritoneal carcinomatosis arising from gastric cancer. Arch Surg 2004;139:20-6. 46. Sumpter K, Harper-Wynne C, Cunningham D et al. Report of two protocol planned interim analyses in a randomised multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF. Br J Cancer. 2005;92:1976-83. 47. Van Cutsem E, Moiseyenko VM, Tjulandin S et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol. 2006;24:4991-7 48. Louvet C, André T, Tigaud JM et al. Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol. 2002;20:4543-8. 49. Seitz JF, Perrier H, Giovannini M et al. 5-Fluorouracil, high-dose folinic acid and mitomycin C combination chemotherapy in previously treated patients with advanced colorectal carcinoma. J Chemother.;10:258-65